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"So nothing unexpected that we saw in safety, which actually gives us a lot of confidence tomove the program forward into phase two," Chakravarthy said, noting that Roche plans to start mid-stage studies in 2025

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Glutathione reductase (GR) which catalyzes the reduction of GSSG using NADPH as a reductant is also a glutathione-linked enzyme involved in cell protection

In the stomach, B12 is released from dietary proteins through the action of gastric acid and pepsin and initially binds to a protein called haptocorrin