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SCALE Obesity and Prediabetes ( NEJM 2015 ) Dosing + Administration Comparison Saxenda requires a daily injection, totalling 365 injections per year

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Instead, mRNA expression is detected in myenteric ganglia in the intestinal mucosa, which are excitable by GLP-1 treatment ex vivo (64% synaptic and 36% after-hyperpolarizing types) (Figure 1 and Table 2)