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Combining CRISPR/Cas9mediated targeted knockdown of receptors in a specific group of neurons with neural circuit manipulation techniques, we dissected the function of LS GLP-1 receptors and LS GLP-1R neurons and uncovered an essential role for these neurons in physiological satiation, as well as a role in generating liraglutide-induced anorectic and weight-reducing effects

When expressed as percent changes from baseline, the NL treatment group had higher vitamin A levels after 2 hours, while the L treatment showed a progressive increase over time, peaking at 6 hours

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Moreover, nucleus and mitochondria contain multiple substrates for caspase-3 [265], which can also provide insight into the non-essential contribution of caspase-3 to eryptosis, since there are no downstream targets of caspase-3 in erythrocytes due to organelle clearance

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