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Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial

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Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJ, Charytan DM, et al

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No excess of clinical cardiovascular events appeared in Phase 2, but Phase 2 was not designed or powered to detect them

these medications are a combination of GLP-1 plus gastric inhibitory polypeptide agonist (GIP) Semaglutide and tirzepatide are marketed for Type 2 diabetes and weight management under different brand names