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As shown, administration of MEL to mice 8 or 4 hours before toxicity inhibited the increase in aminotransferase activity in a dose- and time-dependent manner

Figure 2 Metformin Action on Glucose-Induced Insulin Secretion and Cholinergic Insulinotropic Effect in Isolated Pancreatic Islets As expected, chronic metformin treatment did not change glucose-induced insulin secretion (GIIS) ( Figure 3A )

My concern is that such high levels may have subtle toxic effects

The Focal Adhesion Kinase (FAK) and paxillin are critical components of focal adhesions, which mediate cell adhesion and migration

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