A systematic review in 2025 identified one qualifying clinical study: a retrospective analysis in which 7 of 12 subjects with chronic knee pain reported relief for over six months following intra-articular injection
Depending on the prescribed treatment, peptide therapy may be administered subcutaneously, intramuscularly, orally, or intravenously
Most patients describe a brief, mild sting similar to any standard injection
History of severe hypersensitivity reactions to tirzepatide or any formulation component requires avoidance
Fatigue appears in 8-12% of users, though distinguishing medication-induced fatigue from diet-related energy deficits proves difficult
Proper hydration and protein intake may help support: recovery energy levels muscle maintenance overall wellness Patients sometimes underestimate how much hydration, protein intake, and recovery habits affect how they feel during wellness therapy, says Karla K