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The 2024 Yang paper in Journal for ImmunoTherapy of Cancer documented NNMT in cancer-associated fibroblasts driving tumour progression (PMID 39067875)
There is, per ClinicalTrials.gov, no completed human efficacy trial for 5-Amino-1MQ
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Importantly, AOD-9604 did not produce any of the adverse effects associated with growth hormone therapy, including glucose intolerance, insulin resistance, edema, joint pain, or tissue growth abnormalities
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