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When elevated host oxygenation disrupts the intestinal radial oxygen gradient, it alters the microbial composition, promoting the enrichment of oxygen-tolerant bacteria while significantly suppressing strict anaerobes, such as Anaerostipes, which produce SCFAs (117)

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These mixed results reflected the broader challenge of the oral race: convenience alone was no longer enough to guarantee success oral candidates would have to demonstrate durability, safety, and cardiometabolic value comparable to injectables

2.3 Experimental protocol Following 1 week of acclimation, six rats were allocated randomly to one of four groups: Rats in Group 1, the control group, were given saline intraperitoneally (IP) twice weekly for 6 weeks