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225 One piece of supporting evidence demonstrated that patients exhibiting lower T cell differentiation (characterized by nave or early memory T cell predominance) consistently exhibited superior clinical responses

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Moreover, a recent report demonstrated significantly reduced mitochondrial DNA (mtDNA) copy numbers in cumulusoocyte complexes from PCOS women, accompanied by increased oxidative modifications of mtDNA, confirming that mitochondrial integrity within the gamete microenvironment is severely compromised (61)

Endocrinology 152 , 503514 (2011)

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