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NR4A1 is capable of directly interacting with metformin, influencing the localization of Liver Kinase B1 (LKB1), activating AMPK, and decreasing the generation of inflammatory signals and intracellular ROS

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PMID: 8227353 Secondary Connectivity Map / Broad Transcriptomics Gene Expression Modulation (4,048 Genes) Microarray and CMap analysis reveal that GHK-Cu modulates the expression of 4,048 genes in human fibroblast culturesapproximately 6% of the human genomeaffecting pathways for tissue remodeling, antioxidant defense, anti-inflammatory signaling, and stem cell markers

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