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Conditions such as Crohns disease or Celiac disease can inflame the gut lining, making it difficult for the small intestine to absorb B12 efficiently

Injection site reactions occur in 510 percent of users and vanish completely with oral therapy

References: Cornell University College of Veterinary Medicine

Moreover, although randomized designs mitigate healthy-user bias, participants enrolled in long-term cardiovascular outcome trials may represent a healthier, more adherent subset of patients, potentially limiting generalizability

Your healthcare provider may need to delay dose increases if you experience significant side effects, but should not accelerate the schedule beyond what's recommended in the FDA labeling

Do not self-manage and contact your doctor if the stomach pain did not improve