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Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining

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To, K., Cao, R., Yegiazaryan, A., Owens, J., Nguyen, T., Sasaninia, K., Vaughn, C., Singh, M., Truong, E., Medina, A., Avitia, E., Villegas, J., Pham, C., Sathananthan, A

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Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging

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