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After washing, the cells were incubated with 20 nM Tetramethylrhodamine Ethyl Ester (TMRE) at 37 C for 30 min

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Post hoc analysis of LEADER data revealed a persistent increase in the overall risk of biliary tract-related events and gallbladder diseases, consistently observed across four categories: uncomplicated gallbladder stones, complicated gallbladder stones, cholecystitis with/without gallbladder stones, and biliary obstruction [34]

Notably, under hypoxic or electron transportlimited conditions, SDH can reverse its activity to reduce fumarate to succinate using electrons from the CoQ 10 pool, a metabolic rerouting, allowing cells to maintain redox balance when oxygen is scarce 77

Regulates fibrinogen levels, supports healthy blood flow, and reduces inflammatory signals linked to cardiovascular risk