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It is derived from a protein naturally found in the stomach, which contributes to its strong safety profile

Some people report fewer side effects when injecting into the thigh rather than the stomach, though clinical evidence on this is limited

This creates an itchy sensation even when nothing external irritates the skin

Weight Loss Drugs Always Cause A Stir It doesnt matter what the chemical is or how it is marketed, throughout modern history all new drugs that promise to manage or reduce weight always come with speculation and skepticism even from doctors and physicians

Emili et al., 2022

A 2011 study 26 found similar results, concluding, "These findings suggest that mate may induce anorexic effects by direct induction of satiety and stimulation of GLP-1 secretion"