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176 The second phase of the nervous tissue response is cell proliferation, and this is manifested by proliferation of fibroblasts and pericytes, which form extracellular matrix to produce the fibrotic scar 177,178 that rapidly replaces lost neural parenchyma

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A receptor grid for all the ligands was generated using the Glide application (Schrodinger Release, 2021a) of Maestro (Schrodinger Release, 2021b) within Schrdinger suite (Schrodinger Release, 2021c) by specifying the highest score binding (active) site residues identified by the SiteMap tool (Schrodinger Release, 2021d)

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