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J Clin Endocrinol Metab 93:666673

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But that wont always work

it is impossible to predict in whom this can be done safely, and many people are at risk of worsening symptoms

As a permanently charged quaternary cation it is water-soluble and does not require organic cosolvent for aqueous work, though DMSO stocks are common in cell-based screens

Patients often begin to notice improvement within days to weeks following treatment