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P450 reductase catalysis produces superoxide radicals, which can, in the presence of superoxide dismutase and Fe 3+ , form highly reactive hydroxyl radicals capable of damaging virtually all macromolecules

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Subclinical hypothyroidism (elevated TSH with normal free T4) may also be diagnosed but usually doesnt require treatment because thyroid function often normalizes on its own [4, 5]

Am J Physiol Cell Physiol 298:C407429 Rizzo MA, Fisher M, Lock JP (1993) Hypermagnesemic pseudocoma