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In biochemistry, thiol-metal coordination is well established for copper, zinc, mercury, and cadmium

Common side effects include nausea, reduced appetite, and gastrointestinal symptoms

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Increased sensitivity to cell killing and mutagenesis by chemical mutagens in thymidine-kinase-deficient subclones of a Friend murine leukaemia cell line

Managing these effects through dietary modifications and gradual dose titration is a standard part of GLP-1 therapy