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In adult SAM survivors in Jamaica, a total of 133 CpG sites across 63 genes associated with body size and composition, as well as metabolic pathways involved in immunity, cardiovascular function, and glucose regulation were found to be differentially methylated [134]

The dosage is increased in 2.5 mg increments every 4 weeks until reaching the maximum tolerated dose

Plant Physiol 107:10671073

Conservative approaches extend this to 16-20 weeks for better GI tolerance

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