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If you can tolerate weekly dosing, the evidence strongly supports sticking with it

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Co-treatment of 4d (A2-thio-imidazole derivative), a novel TGR5 agonist, and Sitagliptin (DPP-4 inhibitor) exhibited a GLP-1 secretion and glucose-lowering effect in animal models, while this compound alone exhibits only a slight 1.3-fold increase in GLP-1 secretion [182]

However, this interaction was not required for small molecule agonist TT-OAD2 that elicited cAMP signaling without the presence of an ECD 14

Unlike other GLP-1 medications currently on the market, it is a small-molecule, nonpeptide compound a chemistry distinction with important practical consequences