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Capitalizing on this understanding, nutritional interventions target OA through a multi-tiered approach: (1) Upstream regulation using anti-inflammatory nutrients (e.g., omega-3 fatty acids, polyphenols) to quell systemic inflammation and oxidative stress (10)

Unfortunately, there is limited evidence of antioxidant efficacy [8]

Luo A, Ning P, Lu H, et al

The nicotin in the name is vitamin B3 etymology and bears no relationship to nicotine, a clarification I make at the start of every consult

The same conjugation process clears cortisol metabolites, xenoestrogens from plastics and pesticides, and other endocrine-disrupting chemicals that interfere with hormone signalling

Serious Side Effects and Considerations Though rare, some serious side effects may occur, such as: Pancreatitis : Inflammation of the pancreas, which can be serious if not treated promptly