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This transformation disrupts the hydrogen bonding in bilirubin, converting it into a hydrophilic molecule that cannot be reabsorbed by hepatocytes or intestinal epithelium, thus promoting its excretion [24, 25]

Habbas et al., 2015

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In addition, TA may be oxidized at high temperatures when fused deposition modeling (FDM) is used, which could affect the bioactivity of the hydrogels

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