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During clinical trials, Wegovy demonstrated an average weight loss of 15% over 68 weeks

Metformin is contraindicated when eGFR falls below 30 mL/min/1.73 m2 and dose reduction is recommended when eGFR is 30 to 45 mL/min/1.73 m2, per the FDA Drug Safety Communication (2016)

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They help trigger insulin, slow down how fast your stomach empties, and tell your brain youve had enough to eat