tirzepatide 2.0 Which Weight-Loss Drug Works the Best? FDA approves tirzepatide, Eli Lilly's

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Building on these data, here we assess whether the metabolic effects of such an incretin-conjugated PPAR agonist could further be enhanced by covalent tethering of Tesa to the peptide backbone of the DPP4-protected GLP-1RGIPR co-agonist MAR709 32 (Extended Data Fig