2 Materials and methods 2.1 General computational methods Protein Data Bank (PDB) coordinates of the GLP-1GLP-1R (5VAI) (Zhang et al., 2017), Semaglutide (7KI0), Taspoglutide (7KI1) (Zhang et al., 2021), and liraglutide (4APD) were retrieved from the RCSB PDB server (www.rcsb.org)
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The concentration of -Syn in the CSF of PD patients was remarkably lower than that of normal participants, with the diagnostic sensitivity and specificity of 53.5 and 76.8%, respectively (Shi et al., 2014)
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While medical professionals are excited about understanding this new space in medicine, it's also important that those who use GLP-1s remain cautious and informed of the risks, benefits and proper usage