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Macrophage deletion led to increased tolerance to LPS challenge, but when rBDNF was administered after macrophage depletion, the therapeutic effects of rBDNF were lost, as indicated by no further reduction in histopathological injury, wet-to-dry ratio, BALF protein concentration, immune cell infiltration, and sepsis-induced mouse mortality (Fig

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Jayaprakasha GK, Singh RP, Sakariah KK (2001) Antioxidant activity of grape seed ( Vitis vinifera ) extracts on peroxidation models in vitro

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HCV infection also induces oxidative stress by impairing the thiol/disulfide balance, while direct-acting antiviral therapy restores this balance and decreases the pro-fibrotic process in patients with chronic hepatitis C 101

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