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For example, Th1 cells produce IFN- and IL-2, which play a crucial role in activating macrophages and enhancing T cell cytotoxicity (78)

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In refractory cancers such as glioblastoma, lung, and breast cancer, ABCG2 overexpression is not only a direct mediator of resistance to agents like topotecan and mitoxantrone but also a marker of stemness associated with tumor recurrence (Fig

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