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5.1 GLP1 Agonists Consistent findings of an increased risk of PD in individuals with type 2 diabetes [178] and risk reduction in those treated with certain antidiabetic drug classes including dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide 1 (GLP1) receptor agonists [179,180,181] have moved insulin signaling into the focus of PD research as a target for disease-modifying intervention