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Up to 40% could come from lean mass, which includes muscle

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In a worst-case scenario, improper handling can denature the peptide, breaking its delicate structure and rendering it completely inactive

(Sartain, 2024) By adjusting your dose gradually, you give your body more time to adjust to the change in medication, minimizing the risk of rebound weight gain

Summary: NICE guidance advises against combining Trulicity (a GLP-1 receptor agonist) and Januvia (a DPP-4 inhibitor), recommending that DPP-4 inhibitors be discontinued when starting GLP-1 receptor agonists

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