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The authors of the study concluded that the GLP-1 receptor agonist lixisenatide had a three-point beneficial effect, when compared with placebo, in the change over a 12-month period from a baseline value of approximately 15 points on a 132-point scale measuring motor disability. The active arm improved 0.04 points in the lixisenatide group and worsened 3.04 points in the placebo group

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Verma et al., 2020), FIDELIO-DKD (Sato and Nishimoto, 2025), FLOW (Kidney Disease: Improving Global Outcomes KDIGO CKD Work Group, 2024