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doi: 10.1016/j.exphem.2023.08.001 55 JamrusP.PholngamN.KiatpakdeeB.ViwatpinyoK.VadolasJ.NgampramuanS.et al

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What remains unknown Despite encouraging data, genuine unknowns exist: Effects beyond 6-9 months of continuous use have not been formally studied in animals or humans

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As-needed protocol: Use DSIP only during periods of elevated stress or sleep difficulty Maintain for 2-4 weeks as needed Discontinue when sleep normalizes This conservative approach treats DSIP as a targeted intervention rather than ongoing supplementation

[PubMed] Melkonian EA, Asuka E, Schury MP