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But what is ultimately driving this is your brain, especially in the hypothalamus, is taking information in that says, are you getting enough food for me to consider this a state of abundance where I ramp up your digestion, I ramp up your libido, I ramp up all these things

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Some microdosers even add 3ml of water to create a 3.33mg/ml concentration, making extremely low doses easier to measure

Tirzepatide (Zepbound) achieves about 20-22%

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The "First-Pass" Problem When you swallow a standard pill, it goes through the stomach and then the liver