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Together with the binding of the T cell receptor to the HLAantigen complex, activation of the T cell immune response requires binding of co-stimulatory ligands such as B7 on antigen-presenting cells (APC) to the CD28 receptor on the T cell

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In addition to these observed effects, mild to moderate responses such as gastrointestinal disturbance, cephalic discomfort, and localized dermal reactions at the administration site have also been reported in research subjects

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