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Relatively high succinate levels lead to inhibition of the 2-oxoglutarate (2-OG)-dependent hypoxia-inducible factor (HIF) prolyl-hydroxylases, stabilising HIF-2\(\alpha \) in normoxic (or normal oxygen tensions) conditions leading to a pseudo-hypoxic state with metabolic consequences resembling those seen in cancer described as the Warburg effect (or the so-called aerobic glycolysis) a hallmark of phaeochromocytomas Kluckova and Tennant (2018)

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