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24,25 Previous studies have demonstrated that dual vertical RAS pathway inhibition by targeting Src homology region 2 domain-containing phosphatase 2 (SHP2) and mitogen-activated protein kinase kinase (MAP2K1/2) MEK1/2 or extracellular signaling kinases (MAPK3/1) ERK1/2 leads to synergistic growth inhibition of PDAC tumors