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Weak: Limited human data + reliance on animal studies

Nature 584 , 115119 (2020)

Its defined structure and stability make it suitable for in-vitro and preclinical research models where reproducibility and consistency are essential

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Sinclair, L

Recent analysis shows that the antibodies induced in the small population of SARS-CoV-1-exposed individuals who were subsequently exposed to SARS-CoV-2 appear to be particularly broadly cross-reactive, suggesting that exposure to related coronavirus species can select for cross-reactive antibodies [81]