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Damage to mice by extremely low-frequency electromagnetic fields revealed that lotus root PCs can mediate calcium signals and double the activity of messenger systems through Ca 2+ , CaMK II/CREB, BDNF, and the DG/PKC/MAPK signaling pathways to reverse mouse hippocampal cell oxidative stress and BDNF levels
These various processes contribute to the development of OA by promoting a proinflammatory, catabolic state accompanied by increased susceptibility to cell death that together lead to increased joint tissue destruction and defective repair of damaged matrix