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"Retatrutide represents a promising next step in medical weight management, but it remains an investigational therapy

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TRIUMPH-1: obesity and overweight TRIUMPH-1 (NCT05929066) is the main weight management trial

GLP-1 secreted by the intestine inhibits glucose appearance by inhibiting both nutrient intake and gastric emptying rates while stimulating insulin secretion to facilitate muscle and liver glucose uptake

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(145) presented the primary outcomes of clinical trial programs called SCALE and STEP and studies on the efficacy of GLP-1R agonists in pediatric obesity