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Inflammatory by-products and oxidative stress can stimulate CGRP receptors, indicating their role as detectors of environmental oxidative states (32)
Emerging dual agonists, such as survodutide and cotadutide, which target GLP-1 and glucagon receptors, are being explored for treating metabolically associated fatty liver disease and may also address fatty kidney, a key factor in CKD related to visceral obesity [48]
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The weight loss mechanism differs as well: GLP-1 agonists work through delayed gastric emptying and central appetite suppression, while berberine's weight effects, when present, likely relate to improved insulin sensitivity and metabolic efficiency
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