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They found that despite the large molecular size the smaller factions of beta-glucan penetrate into the skin, even into the dermis (the middle layer of the skin where wrinkles form)

NAD metabolism and oxidative stress: the golden nucleotide on a shaky platform. PMC PubMed Central

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doi: 10.1074/jbc.M602500200 85 FrancoR.CidlowskiJ