The intranasal route was chosen for its ability to bypass the blood-brain barrier, allowing the peptide to reach brain tissue more effectively while minimizing systemic copper exposure
It also plays a central role in the detoxification of various substances, including drugs and harmful chemicals, by binding to them and enabling their removal from the body of research subjects
D-Panthenol (50 mg): It is a form of vitamin B5 that helps support energy metabolism, tissue repair, and proper functioning of the nervous system
2011;342:d1542
Validation of analytical procedures
This is in accordance with our Cu ion content measurement of the PBS and bacterial solution after wet contact killing on Cu-Al alloy samples (Supplementary Figure 4), which is most likely contributing to the lower antibacterial effect, as described in see section 4.4 Bacterial survival after long exposure times is higher within a bacterial community. Another alloy of interest would be Al-Ag-Cu, which has shown to have a greater antibacterial effect compared to Cu-Al alloys on strains of E