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While mild diarrhea is an expected and generally manageable side effect of semaglutide, certain warning signs require prompt medical evaluation

Malhotra continues

Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]

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According to WHO, about 422 million people are affected by diabetes and about 1.5 million per year deaths have been reported worldwide