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In the absence of MTAP, endogenous MTA cannot be salvaged into methionine, leading to the accumulation of dcSAM and MTA, both of which inhibit methylation reactions

doi: 10.1139/y82-201

This study was supported by the following grants funded to PA: Grant Funded by the European Union -Next Generation EU PRIN 2022 PNRR (Project no

Gunter et al., 2017)

Although 25 selenoproteins are tissue-specific finetuned in Se deficiency (85) and deiodinase is a highly conserved selenoprotein, the content activity of deiodinase also decreases in severe Se deficiency, when the body synthesizes significantly less T3 and the inhibitory effect on TSH is diminished

however, other researchers indicate an equal share of both sources [39]