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In nonalcoholic steatohepatitis (NASH, also known as metabolic dysfunction-related steatohepatitis, MASH), macrophages expressing Trem2 play a key role in promoting its development into hepatocellular carcinoma (HCC)

Effect of saxagliptin monotherapy in treatment-nave patients with type 2 diabetes

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In all three neuronal clusters, we found a similar pattern of gene expression changes after treatment with the GIPR antagonist and acyl-GLP-1, with 29 genes in the C35 Glut10 cluster, 29 genes in the C35 GABA4 cluster and 45 genes in the C35 GABA3 cluster affected by both GLP-1R agonism and GIPR antagonism (Fig