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Other benefits of MOTS-c MOTS-cs diverse therapeutic effects may help users realize numerous downstream health effects: Diabetes: Inefficient glucose uptake is a characteristic of type 2 diabetes, and mitochondrial dysfunction may result in two risk factors for the disease insulin resistance and impaired insulin secretion.32 33 MOTS-cs actions on these risk factors may help nip them in the bud.34 Cardiovascular health: Diabetes is a cardiovascular risk factor, so cutting it from the picture can spell significant improvements in heart health.35 A high body-fat percentage is another such risk factor, so if MOTS-c can prevent obesity, it can halt the onset of a health condition characteristic of more than 80% of people with coronary heart disease.36 37 Longevity: Given the link between inflammation, age, and high-risk age-related diseases (e.g., atherosclerosis, cardiovascular disease), MOTS-c may increase lifespan as a continual downstream effect.38 Cognitive function: A 2022 review published in Progress in Neurobiology noted that metabolic modulators (which MOTS-c is) and exercise (which MOTS-c simulates) can be used in neuroprotective strategies.39 Or at least that has been the case in preclinical studies

CrossRef Advanced Oxidation Protein Products Contribute to Chronic-Kidney-Disease-Induced Adipose Inflammation through Macrophage Activation Nanaka Arimura, Hiroshi Watanabe, Hiromasa Kato, Tadashi Imafuku, Takehiro Nakano, Miyu Sueyoshi, Mayuko Chikamatsu, Kai Tokumaru, Taisei Nagasaki, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Toru Maruyama Toxins.2023