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In human nocturnal sleep, SWS predominates initially and decreases in intensity and duration throughout the course of sleep

pmid: 1197343 3DavisBR, Lee-KongSA, MigalyJ, FeingoldDL, SteeleSR

Tirzepatide adds GIP receptor activation on top of GLP-1 signaling, engaging additional metabolic control points

N Engl J Med 373:232242 Scirica BM, Bhatt DL, Braunwald E et al (2013) Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus