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These effects, in conjunction with potential sleep-enhancing benefits observed in patients with dementia treated with melatonin [214], provide a compelling rationale for hypothesizing that supplementing melatonin near bedtime may augment the glymphatic systems clearance function

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This approach moves beyond simply diagnosing an MI to uncovering its specific pathophysiological drivers

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Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn's disease