When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
One of the primary ways is through food because L-Carnitine is present in animal-based products like red meat, chicken, fish, and also in milk and other dairy products
None of these interactions is a reason to avoid the supplements outright, but they are good reasons to involve a clinician
By fueling muscles with a steady supply of energy, L-Carnitine helps improve endurance so you can train harder, longer, and recover faster
[4] AOD9604 for Osteoarthritis and Joint Health This is where AOD9604 gets really interesting
doi: 10.1002/mrd.10102 39 HarrisSELeeseHJGosdenRGPictonHM