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[53] Tirzepatide's efficacy for chronic weight management (weight reduction and maintenance) in combination with a reduced-calorie diet and increased physical activity was established in two randomized, double-blind, placebo-controlled trials in adults with obesity or overweight who had at least one weight-related condition

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Second, COP1 recognizes substrates via its WD40 domain and engages DET1 through asymmetric WD40-DET1 interfaces, consistent with a COP1 dimer bound to a single DET1

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