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doi: 10.1038/nmeth1019 18 BenjaminiYHochbergY

While the GIPR antagonist alone provides little weight loss in DIO mice, its combination with the GLP-1R agonist liraglutide nearly doubles the weight loss seen with liraglutide alone

Eur J Heart Fail 22:14951503 Seferovi PM, Fragasso G, Petrie M, Mullens W, Ferrari R, Thum T, Bauersachs J, Anker SD, Ray R, avuolu Y, Polovina M, Metra M, Ambrosio G, Prasad K, Seferovi J, Jhund PS, Dattilo G, elutkiene J, Piepoli M, Moura B, Chioncel O, Ben Gal T, Heymans S, Jaarsma T, Hill L, Lopatin Y, Lyon AR, Ponikowski P, Lainak M, Jankowska E, Mueller C, Cosentino F, Lund LH, Filippatos GS, Ruschitzka F, Coats AJS, Rosano GMC (2020) Heart Failure Association of the European Society of Cardiology update on sodium-glucose co-transporter 2 inhibitors in heart failure

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Another benefit is the steady momentum created by glp 1 weight loss programs